Open science book with sirtuins article on left and colorful labeled cellular diagrams on right.

A Brief Guide to Sirtuins 2025

What Are Sirtuins?

Sirtuins are a family of proteins that act like tiny cellular managers. They help control how cells use energy, repair damage, and respond to stress. Think of sirtuins as switches that help cells stay healthy and efficient as we age.

Why Do Sirtuins Matter For Health & Ageing?

Sirtuins support key processes linked to longevity and wellbeing: energy production, DNA repair, inflammation control, and metabolic balance. When sirtuins work well, cells recover faster, tissues stay stronger, and the body handles stress better. Low sirtuin levels speed ageing, disrupt metabolism, and weaken stress recovery.

Blank spiral notebook centered among bowls of cookies, plums, green fruits, nuts, pumpkin seeds, wafer sticks, and syrup.


How Sirtuins Work (Simple Explanation)

  • Sirtuins need a molecule called NAD+ to do their job.
  • High NAD+ turns on sirtuins, which fix DNA, lower inflammation, and power mitochondria.Β 
  • When NAD+ drops common with ageing and long-term stress, sirtuin activity falls too, and cells lose some resilience.


Key Sirtuin Types To Know

  • SIRT1: Often called the longevity sirtuin; helps with DNA repair, inflammation control, and metabolic balance.
  • SIRT3: Works mainly in mitochondria; keeps cellular energy production efficient.
  • SIRT6: Important for genome stability and metabolic health.

Different sirtuins work in different cell parts, but they all rely on NAD+ and help cells stay youthful.

Cell map: SIRT1, SIRT3, SIRT6 in nucleus; SIRT7 in nucleolus; SIRT2 in cytoplasm; SIRT3, SIRT4, SIRT5 in mitochondria


Lifestyle Ways To Support Sirtuins (Evidence-Based, Easy Steps)

  • Move Regularly: Moderate exercise boosts NAD+ and activates sirtuins.
  • Sleep Well: Quality sleep helps hormone balance and cellular repair.
  • Eat Nutrient-Rich Foods: Foods high in polyphenols (berries, green tea), omega-3s, magnesium, and protein support sirtuin pathways.
  • Practice Time-Restricted Eating or Modest Fasting: Controlled eating windows can raise NAD+ and stimulate sirtuin activity.
  • Manage Stress: Mindfulness, breathing, and gentle movement lower chronic cortisol that can harm NAD+ and sirtuins.

How Do Supplements Fit In? (Where LLG+ Comes In!)

LLG+ focuses on cellular resilience and practical longevity. Our approach supports sirtuins by restoring the cellular fuel they need, NAD+ precursors while adding complementary co-nutrients:

  • NAD+ Precursors: Provide building blocks to restore NAD+ so sirtuins can work efficiently.
  • B-complex and Minerals: Support energy metabolism and cofactor needs for sirtuin-related reactions.
  • Antioxidants and D3: Reduce oxidative stress and support immune and metabolic health.
  • Absorption-first Formulation: Nutrients in forms the body can use quickly, reducing waste and boosting impact.

LLG+ gives NAD+ and key nutrients to turn on sirtuins, ease cell stress, and help you age healthier.Β 

Person reads label on a dark bottle using a smartphone for reference, bottles and kitchen in background.


Practical Daily Plan To Support Sirtuins (What You Can Do Now)

  1. Morning: Light movement or a walk; protein-rich breakfast with berries.
  2. Midday: Prioritize whole foods and hydration; short mindfulness or breathing breaks.
  3. Afternoon: Gentle activity to avoid long sedentary stretches.
  4. Evening: Wind down screen time; aim for a consistent sleep schedule.
  5. Supplement: Take LLG+ as directed to restore NAD+ precursors and cofactors.

Who Benefits Most From Sirtuin Support?

People seeking better energy, mental clarity, and resilience particularly those with stressful, sleep‑disrupted, or hectic routines. Sirtuin support benefits all adults, and it’s more effective the sooner you begin alongside healthy habits.Β 

Common Questions (Quick Answers)

  • Will supporting sirtuins reverse ageing?
    No; it helps slow cellular decline and improve resilience, but it’s not a reversal magic bullet.
  • Are sirtuin-boosting strategies safe?
    Generally yes, when done sensibly: balanced nutrition, moderate exercise, and responsible supplement use. Check with a healthcare professional if you have medical conditions or take prescription medicines.
  • How fast will I notice changes?
    Some people feel better within weeks (more energy, better sleep); cellular benefits accrue over months.

Final Word β€” LLG+ Perspective

Sirtuins are a powerful, natural pathway your body already uses to protect and repair itself. In 2025, the clearest, safest approach is a combined strategy: smart lifestyle habits plus targeted nutritional support. LLG+ boosts NAD+ and key nutrients to help sirtuins support healthy cells, so you feel stronger and more energetic.Β 

Back to blog